Kaletra Explained: Uses, Dosage, Side Effects & FAQs
A clear, up‑to‑date guide on Kaletra - what it does, how to take it, common side effects, drug interactions and practical tips for patients and caregivers.
Lopinavir/Ritonavir – Quick Guide
If you’ve seen the name lopinavir/ritonavir on a prescription label, you might wonder what it actually does. In plain terms, it’s a combo of two antiviral drugs that work together to stop certain viruses from multiplying. Doctors mostly use it for HIV infection, and it was also tried for COVID‑19 early in the pandemic.
How It Works
Lopinavir is the main virus‑blocking ingredient. It stops the virus from cutting up its proteins, which the virus needs to build new copies of itself. Ritonavir on its own isn’t a strong antiviral, but it slows down the breakdown of lopinavir in the liver. That means lopinavir stays in your blood longer and does a better job.
The two pills are usually packed together in a single tablet, so you only have to take one dose a day. For HIV, the standard dose is 400 mg of lopinavir with 100 mg of ritonavir, taken twice a day with food. Eating helps the medicine absorb better and can reduce stomach upset.
When COVID‑19 hit, some hospitals gave lopinavir/ritonavir to patients hoping it would cut down the virus. Large studies later showed it didn’t make a big difference for most patients, so it’s no longer a front‑line COVID‑19 drug. Still, the combo remains a key part of HIV treatment regimens.
Safety and Side Effects
Like any medication, lopinavir/ritonavir can cause side effects. The most common are nausea, diarrhea, and a metallic taste in the mouth. Those usually settle after a few days, especially if you take the pill with a meal.
Some people notice higher blood fats, such as cholesterol or triglycerides. Your doctor may check your blood work regularly and suggest diet changes or a cholesterol‑lowering medicine if needed.
Because ritonavir blocks liver enzymes, it can interact with many other drugs. Always tell your doctor about any other prescriptions, over‑the‑counter meds, or supplements you’re taking. Missing doses can also let the virus bounce back, so set a reminder or use a pill box.
If you experience severe stomach pain, yellowing of the skin or eyes, or an allergic rash, call your healthcare provider right away. Those are rare but need fast attention.
Overall, lopinavir/ritonavir is a well‑studied antiviral that helps many people keep the virus under control. Knowing how to take it properly, watching for side effects, and keeping your doctor in the loop will give you the best chance of staying healthy.
Have more questions about your prescription? Talk to your pharmacist—they can explain the dosing schedule, what to expect, and how to handle any issues that pop up.